The Era of Personalized Cancer Therapeutics

  Isabel Levy & Seema Bachoo Glossary Adoptive T cell transfer, Allosteric site, Clonal expansion, CRISPR-Cas9, DNA, DNA sequencing, EGFR, ‘Gain-of-function’ mutation, Genome, Genomic Instability, GTPase, GDP, GTP, Kinase, ‘Loss-of-function’ mutation, MAPK signaling pathway, Mutation, Oncogene/Proto-oncogene,  Personalized Cancer Medicine, PI3K pathway, RAS, TP53 gene, Tumor suppressor gene   Background Cancer: a disease of the genome […]

Human African trypanosomiasis (HAT): past to present and beyond

Aaron Logsdon   Abbreviations BBB, Blood brain barrier; DDT, dichlorodiphenyltrichloroethane; DRC, the Democratic Republic of the Congo; HAT, Human African Trypanosomiasis; NECT, nifurtimox-eflornithine combination therapy; NTD, neglected tropical disease; ODC, ornithine decarboxylase; VSG, variant surface glycoprotein   Glossary antigen, antigenic variation, arsenic, asymptomatic, clinical trial, dementia, drug, drug resistance, energy metabolism, endemic, epidemic, fever, host, […]

What is Digital Health and how is it revolutionizing healthcare?

Olivia Crossley   Keywords Arrhythmia, Artificial intelligence, Blood Pressure, Consultant, Digital health, Electrodes, EEG, ECG, FDA, Machine Learning, Side effects, Telemedicine, Ultrasound, UK’s General Data Protection Regulation, Wearable technologies Digital technologies are electronic devices that analyze and store different kinds of information. These technologies have revolutionized how we communicate, learn, and shop. Now, digital devices […]

What is phage therapy and could it be used as an alternative to antibiotics?

  Sam Jarada   Glossary bactericidal, bacteriostatic, capsid, cell wall, DNA gyrase, dosage, dysentery, efficacy, enzyme, microbiome, lipid, lysis, lytic, nucleic acid, pathogenic, placebo, RNA, transcription, translation Introduction Phage therapy is a type of treatment that makes use of bacteriophages (phages), (a type of virus that only infect bacteria). Phages are composed of a nucleic […]

What is CAR-T cell therapy?

Seema Bachoo   Immunotherapy is a type of cancer treatment that makes use of a patient’s own immune system to target and destroy cancer cells, with the aim of eliminating cancer from the body. There are several different types of immunotherapies. Cytokine-based immunotherapies harness the power of cytokines, which are soluble proteins that stimulate and […]

What is meant by the terms Personalized and Precision Medicine?

Lovisa Lindquist Currently, the majority of healthcare systems around the world employ a ‘one-size-fits-all’ approach when treating patients that have been diagnosed with the same disease, meaning that people with the same diagnosis will most likely be prescribed the same treatment [1]. However, through the use of sophisticated molecular techniques that have been developed in […]