Advanced Therapies Europe 2022

  The Advanced Therapies Europe 2022 conference focused on exploring the commercialization of advanced therapy medicinal products (ATMPs), with talks on patient access, the manufacturing chain, and clinical case studies of cell and gene therapies. The event targeted Europeans looking for global growth as well as the global audience aiming to expand into the European […]

What is phage therapy and could it be used as an alternative to antibiotics?

  Sam Jarada   Glossary bactericidal, bacteriostatic, capsid, cell wall, DNA gyrase, dosage, dysentery, efficacy, enzyme, microbiome, lipid, lysis, lytic, nucleic acid, pathogenic, placebo, RNA, transcription, translation Introduction Phage therapy is a type of treatment that makes use of bacteriophages (phages), (a type of virus that only infect bacteria). Phages are composed of a nucleic […]

Genomics: The Advent of Preventative Medicine?

Olivia Crossley   Glossary Amniocentesis, Cell, Amyotrophic lateral sclerosis,  Chorionic villus sampling,  Chromosome, COVID-19, CRISPR-Cas9,  Cystic fibrosis, DNA, Duchenne Muscular Dystrophy, Etiology, Familial Hypercholesterolemia, Gene, Genetic Counselling, Genetic Testing, Hemophilia, Leopard syndrome, Mucopolysaccharidosis type I,  Noncoding DNA, Parkinson’s disease, Pharmacogenomics, Phenylketonuria, Precision Medicine, Prenatal testing,  Severe Combined Immunodeficiency Disorder, Spinal Muscular Atrophy   What is […]

COVID-19: How will testing and vaccines have to adapt to new variants?

Joana Vidigueira   Abbreviations SARS: Severe Acute Respiratory Syndrome, CoV: coronavirus, MERS: Middle Eastern Respiratory Syndrome, DNA: deoxyribonucleic acid, RNA: ribonucleic acid, ACE2: angiotensin-converting enzyme 2, APC: antigen presenting cells, mRNA: messenger RNA, RT-PCR: reverse transcription polymerase chain reaction Introduction Viruses are biological agents that are only able to survive and multiply within a living […]

What is CAR-T cell therapy?

Seema Bachoo   Immunotherapy is a type of cancer treatment that makes use of a patient’s own immune system to target and destroy cancer cells, with the aim of eliminating cancer from the body. There are several different types of immunotherapies. Cytokine-based immunotherapies harness the power of cytokines, which are soluble proteins that stimulate and […]

Pharmacogenomics: The future of medicine?

Celeste Cohen           Picture credit: National Human Genome Research Institute         Note: All terms shown in bold are defined in the glossary at the end of the article. Defining Pharmacogenomics From chemotherapy to HIV drugs, the past century has seen rapid advances in medical innovation, which have given rise to a wide range […]

How immunotherapy can improve colorectal cancer prognosis

Aaron Logsdon   Abbreviations CAR, chimeric antigen receptor; CAR-T, chimeric antigen receptor T lymphocyte therapy; CRC, colorectal cancer; DCR, disease control rate; dMMR, mismatch repair-deficient; FDA, US Food and Drug Administration; ICI, immune checkpoint inhibition; MMR, mismatch repair genes; MSI-H, high microsatellite instability; MSS, microsatellite stable; OR, objective response; pMMR, mismatch repair proficient; Treg, T […]

What is meant by the terms Personalized and Precision Medicine?

Lovisa Lindquist Currently, the majority of healthcare systems around the world employ a ‘one-size-fits-all’ approach when treating patients that have been diagnosed with the same disease, meaning that people with the same diagnosis will most likely be prescribed the same treatment [1]. However, through the use of sophisticated molecular techniques that have been developed in […]

Advanced Therapies Congress & Expo 2021

On the 5th of October, 2021, PMM team members Celeste Cohen, Shannon Hylton, and Aaron Logsdon attended the Advanced Therapies Congress held at the London ExCeL. The Advanced Therapies Congress explored, defined, and attempted to tackle the main challenges currently being faced when it comes to the development of patient access to advanced therapy medicinal products […]