The Era of Personalized Cancer Therapeutics

  Isabel Levy & Seema Bachoo Glossary Adoptive T cell transfer, Allosteric site, Clonal expansion, CRISPR-Cas9, DNA, DNA sequencing, EGFR, ‘Gain-of-function’ mutation, Genome, Genomic Instability, GTPase, GDP, GTP, Kinase, ‘Loss-of-function’ mutation, MAPK signaling pathway, Mutation, Oncogene/Proto-oncogene,  Personalized Cancer Medicine, PI3K pathway, RAS, TP53 gene, Tumor suppressor gene   Background Cancer: a disease of the genome […]

Human African trypanosomiasis (HAT): past to present and beyond

Aaron Logsdon   Abbreviations BBB, Blood brain barrier; DDT, dichlorodiphenyltrichloroethane; DRC, the Democratic Republic of the Congo; HAT, Human African Trypanosomiasis; NECT, nifurtimox-eflornithine combination therapy; NTD, neglected tropical disease; ODC, ornithine decarboxylase; VSG, variant surface glycoprotein   Glossary antigen, antigenic variation, arsenic, asymptomatic, clinical trial, dementia, drug, drug resistance, energy metabolism, endemic, epidemic, fever, host, […]

The use of Stem Cells in Modern Medicine

Lovisa Lindquist   Abbreviations CNS, central nervous system; ESC, embryonic stem cell; FDA, Food & drug administration; HLA, human leukocyte antigen; HSC, hematopoietic stem cell; ICM, inner cell mass; iPSC, induced pluripotent stem cell; IVF, in vitro fertilization; MS, multiple sclerosis; MSC, mesenchymal stem cells; SC, stem cell Glossary Adipose tissue, Amniotic sac, Antigen, Autoimmune […]

What is Digital Health and how is it revolutionizing healthcare?

Olivia Crossley   Keywords Arrhythmia, Artificial intelligence, Blood Pressure, Consultant, Digital health, Electrodes, EEG, ECG, FDA, Machine Learning, Side effects, Telemedicine, Ultrasound, UK’s General Data Protection Regulation, Wearable technologies Digital technologies are electronic devices that analyze and store different kinds of information. These technologies have revolutionized how we communicate, learn, and shop. Now, digital devices […]

Advanced Therapies Congress, 24-25 May, 2022, ExCel, London

On the 24th of May, 2022, PMM team members, Xuanqi Song and Sam Jarada, attended the Advanced Therapies Congress held at the London ExCeL. The Advanced Therapies Congress explored, defined, and attempted to tackle the main challenges currently being faced when it comes to the development of patient access to advanced therapy medicinal products (ATMP). […]

Genomics: The Advent of Preventative Medicine?

Olivia Crossley   Glossary Amniocentesis, Cell, Amyotrophic lateral sclerosis,  Chorionic villus sampling,  Chromosome, COVID-19, CRISPR-Cas9,  Cystic fibrosis, DNA, Duchenne Muscular Dystrophy, Etiology, Familial Hypercholesterolemia, Gene, Genetic Counselling, Genetic Testing, Hemophilia, Leopard syndrome, Mucopolysaccharidosis type I,  Noncoding DNA, Parkinson’s disease, Pharmacogenomics, Phenylketonuria, Precision Medicine, Prenatal testing,  Severe Combined Immunodeficiency Disorder, Spinal Muscular Atrophy   What is […]

COVID-19: How will testing and vaccines have to adapt to new variants?

Joana Vidigueira   Abbreviations SARS: Severe Acute Respiratory Syndrome, CoV: coronavirus, MERS: Middle Eastern Respiratory Syndrome, DNA: deoxyribonucleic acid, RNA: ribonucleic acid, ACE2: angiotensin-converting enzyme 2, APC: antigen presenting cells, mRNA: messenger RNA, RT-PCR: reverse transcription polymerase chain reaction Introduction Viruses are biological agents that are only able to survive and multiply within a living […]

What is CAR-T cell therapy?

Seema Bachoo   Immunotherapy is a type of cancer treatment that makes use of a patient’s own immune system to target and destroy cancer cells, with the aim of eliminating cancer from the body. There are several different types of immunotherapies. Cytokine-based immunotherapies harness the power of cytokines, which are soluble proteins that stimulate and […]

How immunotherapy can improve colorectal cancer prognosis

Aaron Logsdon   Abbreviations CAR, chimeric antigen receptor; CAR-T, chimeric antigen receptor T lymphocyte therapy; CRC, colorectal cancer; DCR, disease control rate; dMMR, mismatch repair-deficient; FDA, US Food and Drug Administration; ICI, immune checkpoint inhibition; MMR, mismatch repair genes; MSI-H, high microsatellite instability; MSS, microsatellite stable; OR, objective response; pMMR, mismatch repair proficient; Treg, T […]

What is meant by the terms Personalized and Precision Medicine?

Lovisa Lindquist Currently, the majority of healthcare systems around the world employ a ‘one-size-fits-all’ approach when treating patients that have been diagnosed with the same disease, meaning that people with the same diagnosis will most likely be prescribed the same treatment [1]. However, through the use of sophisticated molecular techniques that have been developed in […]